Horny Goat Weed (Epimedium Grandiflorum. Epimedium Epimedium Sagitatum) Research References
1: Wang ZQ, Lou YJ.  
  Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.
Eur J Pharmacol. 2004 Nov 19;504(3):147-53.
2: Oh MH, Houghton PJ, Whang WK, Cho JH.  
  Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity.
Phytomedicine. 2004 Sep;11(6):544-8.
3: Ma A, Qi S, Xu D, Zhang X, Daloze P, Chen H.  
  Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo.
Transplantation. 2004 Sep 27;78(6):831-8.
4: Kong X, Hu Y, Rui R, Wang D, Li X.  
  Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken.
Int Immunopharmacol. 2004 Jul;4(7):975-82.
5: Liu XH, Xu LJ, Zhu JH.  
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Zhongguo Zhong Yao Za Zhi. 2003 Apr;28(4):335-6. Chinese.
6: Guo BL, Xiao PG.  
  [Comment on main species of herba epimedii]
Zhongguo Zhong Yao Za Zhi. 2003 Apr;28(4):303-7. Chinese.
7: Sun Y, Fung KP, Leung PC, Shi D, Shaw PC.  
  Characterization of medicinal Epimedium species by 5S rRNA gene spacer sequencing.
Planta Med. 2004 Mar;70(3):287-8.
8: Geng XF, Pang XY, Li GZ.  
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Zhongguo Zhong Yao Za Zhi. 2003 Jun;28(6):488-90. Review. Chinese.
9: Liu HD, Lin FS, Li E, Wu MS, Tong XX.  
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Zhongguo Zhong Yao Za Zhi. 2003 Mar;28(3):262-5. Chinese.
10: Wang S, Zheng Z, Weng Y, Yu Y, Zhang D, Fan W, Dai R, Hu Z.  
  Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts.
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11: Chen Y, Shen ZY, Chen WH.  
  [Molecular mechanism of epimedium flavonoids in immune homeostasis remodeling in aged rats revealed by lymphocyte gene expression profile]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Jan;24(1):59-62. Chinese.
12: Chen KM, Ge BF, Ma HP, Zheng RL.  
  The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro.
Pharmazie. 2004 Jan;59(1):61-4.
13: Lin CC, Ng LT, Hsu FF, Shieh DE, Chiang LC.  
  Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth.
Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):65-9.
14: Wu BY, Zou JH, Meng SC.  
  [Effect of wolfberry fruit and epimedium on DNA synthesis of the aging-youth 2BS fusion cells]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Dec;23(12):926-8. Chinese.
15: Wang S, Wu Y, Ju Y, Chen X, Zheng W, Hu Z.  
  On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of flavonoids in Epimedium brevicornum Maxim.
J Chromatogr A. 2003 Oct 31;1017(1-2):27-34.
16: Chao SL, Huang LW, Yen HR.  
  Pregnancy in premature ovarian failure after therapy using Chinese herbal medicine.
Chang Gung Med J. 2003 Jun;26(6):449-52.
17: Wu H, Lien EJ, Lien LL.  
  Chemical and pharmacological investigations of Epimedium species: a survey.
Prog Drug Res. 2003;60:1-57. Review.
18: Jiang YN, Mo HY, Chen JM.  
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Zhongguo Zhong Yao Za Zhi. 2002 Mar;27(3):221-4. Chinese.
19: Wei RB, Huo HR, Li XQ, Zhou AX, Shen H, Tian JL.  
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Zhongguo Zhong Yao Za Zhi. 2002 Mar;27(3):215-8. Chinese.
20: Mao H, Zhang L, Wang Y, Wen P, Cui S.  
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Zhong Yao Cai. 1999 Jan;22(1):35-6. Chinese.
21: Wang DX, Yang GL, Song XR, Kou SR.  
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Se Pu. 2001 Jan;19(1):64-7. Chinese.
22: Ye LC, Chen JM.  
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Zhongguo Zhong Yao Za Zhi. 2001 May;26(5):293-5.
23: Jiang YN, Yu ZP, Yang ZM, Chen JM.  
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Zhongguo Zhong Yao Za Zhi. 2001 Feb;26(2):105-8.
24: Chen HL, Wang JK, Ren YQ, Wu ZY.  
  [Contents of ten trace elements in Epimedium acuminatum Franch. and its different processed products]
Zhongguo Zhong Yao Za Zhi. 2001 Mar;26(3):159-61.
25: Chen HL, Wang JK, Zhang LL, Wu ZY.  
  [Contents of general flavonoides in Epimedium acuminatum Franch. and its differently-processed products]
Zhongguo Zhong Yao Za Zhi. 2000 Apr;25(4):239-41.
26: Li J, Yu S, Li T, Pang S.  
  In vitro study of the effects of Epimedium on osteoclastic bone resorption in various oral mineralized tissues.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 Sep;37(5):391-4.
27: Jia X, Wu J, Mao Q.  
  [Chemical constituents of Epimedium acuminatum Franch. (II)]
Zhongguo Zhong Yao Za Zhi. 1998 Dec;23(12):737-9, 765.
28: Yan W, Fu Y, Ma Y, Li Y, Zhang X, Xin F.  
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Zhongguo Zhong Yao Za Zhi. 1998 Dec;23(12):735-6, 764.
29: Gau S, Fu D, Zhang H.  
  [Advances in the study on the treatment of osteoporosis with Epimedium brevicornum and its compound prescription]
Zhongguo Zhong Yao Za Zhi. 1999 Apr;24(4):249-51. Review. Chinese. No abstract available.
 
30: Du Q, Xia M, Ito Y.  
  Purification of icariin from the extract of Epimedium segittatum using high-speed counter-current chromatography.
J Chromatogr A. 2002 Jul 12;962(1-2):239-41.
31: Chiba K, Yamazaki M, Umegaki E, Li MR, Xu ZW, Terada S, Taka M, Naoi N, Mohri T.  
  Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells.
Biol Pharm Bull. 2002 Jun;25(6):791-3.
32: Sun P, Wen Y, Xu Y, Pei Y, Chen Y, Shimizu N, Takeda T.  
  [The chemical constituents of Epimedium koreanum Nakai]
Yao Xue Xue Bao. 1998 Dec;33(12):919-22. Chinese.
33: Hsieh TC, Lu X, Guo J, Xiong W, Kunicki J, Darzynkiewicz Z, Wu JM.  
  Effects of herbal preparation Equiguard on hormone-responsive and hormone-refractory prostate carcinoma cells: mechanistic studies.
Int J Oncol. 2002 Apr;20(4):681-9.
34: Wang C, Li Y, Wang Y.  
  [A review of pharmacological study on Epimedium grandiflorum Morr and its active constituents]
Zhongguo Zhong Yao Za Zhi. 1998 Mar;23(3):183-5. Review. Chinese. No abstract available.
35: Jia X, Wu J, Mao Q.  
  [Chemical constituents of the root of Epimedium acumiantum Franch]
Zhongguo Zhong Yao Za Zhi. 1998 Mar;23(3):162-4, 192. Chinese.
36: Cai D, Shen S, Chen X.  
  [Clinical and experimental research of Epimedium brevicornum in relieving neuroendocrino-immunological effect inhibited by exogenous glucocorticoid]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Jan;18(1):4-7. Chinese.
37: Wang B, Quan J, Guo S.  
  [Effects of epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat]
Zhonghua Fu Chan Ke Za Zhi. 2000 Dec;35(12):724-6. Chinese.
38: Ma Z, Wang R, Qiu M.  
  [Study of morphologic effects of 4 Chinese herbs by bone histomorphometry in ovariectomized rats]
Zhonghua Fu Chan Ke Za Zhi. 1999 Feb;34(2):82-5.
39: He S, Guo B.  
  [Observation of pollen morphology of medicinal Epimedium plants in Guizhou province by SEM]
Zhongguo Zhong Yao Za Zhi. 1997 May;22(5):268-70, 318.
40: Xu M, Cheng Z.  
  [Advances in the chemical study of Epimedium]
Zhongguo Zhong Yao Za Zhi. 1997 Oct;22(10):631-2. Review. Chinese. No abstract available.
41: Kuroda M, Mimaki Y, Sashida Y, Umegaki E, Yamazaki M, Chiba K, Mohri T, Kitahara M, Yasuda A, Naoi N, Xu ZW, Li MR.  
  Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.
Planta Med. 2000 Aug;66(6):575-7.
42: Zhao Y, Cui Z, Zhang L.  
  [Effects of icariin on the differentiation of HL-60 cells]
Zhonghua Zhong Liu Za Zhi. 1997 Jan;19(1):53-5.
43: Peng G, Fu M, Zhang D.  
  [The experimental study about the relations between Chinese herb-epimedium leptorrhizum stearn (CH-ELS) and endogenous cAMP in alveolar bone of orthodontic tooth in rats]
Zhonghua Kou Qiang Yi Xue Za Zhi. 1997 Jan;32(1):40-2.
44: Tan X, Weng W.  
  [Efficacy of epimedium compound pills in the treatment of the aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases]
Hunan Yi Ke Da Xue Xue Bao. 1998;23(5):450-2.
45: Yu S, Chen K, Li S, Zhang K.  
  In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption.
Chin J Dent Res. 1999 Feb;2(1):7-11.
46: Chen C, Sha M, Yang S, Zhang Z.  
  [Quantitative study of magnoflorine in Epimedium koreanum Nakai.]
Zhongguo Zhong Yao Za Zhi. 1996 Nov;21(11):681-2, 704.
47: Wu T, Cui L, Zhang Z, Chen Z, Li Q, Liao J, Huang L.  
  [Experimental study on antagonizing action of herba Epimedii on side effects induced by glucocorticoids]
Zhongguo Zhong Yao Za Zhi. 1996 Dec;21(12):748-51, 763.
48: Sun PY, Chen YJ, Wen Y, Pei YP, Liu ZH, Yao XS, Takeda T, Ogihara Y.  
  [Structure determination of korepimedoside A and korepimedoside B from Epimedium koreanum Nakai]
Yao Xue Xue Bao. 1996;31(8):602-6.
49: Guo B, Xiao P.  
  [Determination of flavonoids in different parts of five epimedium plants]
Zhongguo Zhong Yao Za Zhi. 1996 Sep;21(9):523-5, 574.
50: Li W, Guo B, Xiao P, Pan J, Lu M, Zhang R.  
  [Chemical constituents of Epimedium wanshanense S. Z. He et Guo]
Zhongguo Zhong Yao Za Zhi. 1996 Oct;21(10):614-6, 640.
51: Gao B, Yu J, Xiao P.  
  [Chemical constituents from the aerial part of Epimedium brevicornum Maxim.]
Zhongguo Zhong Yao Za Zhi. 1996 May;21(5):290-2, 319.
52: Guo B, Yu J, Xiao P.  
  [Chemical constituents from the whole plant of Epimedium fargesii Franch.]
Zhongguo Zhong Yao Za Zhi. 1996 Jun;21(6):353-5, 383.
53: Liang HR, Vuorela P, Vuorela H, Hiltunen R.  
  Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense.
Planta Med. 1997 Aug;63(4):316-9.
54: Liang HR, Siren H, Jyske P, Reikkola ML.  
  Characterization of flavonoids in extracts from four species of Epimedium by micellar electrokinetic capillary chromatography with diode-array detection.
J Chromatogr Sci. 1997 Mar;35(3):117-25.
55: Li WK, Zhang RY, Xiao PG.  
  Flavonoids from Epimedium wanshanense.
Phytochemistry. 1996 Sep;43(2):527-30.
56: Li WK, Pan JQ, Lu MJ, Xiao PG, Zhang RY.  
  Anhydroicaritin 3-O-rhamnosyl(1-->2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1-->2, 1-->3 and 1-->4)rhamnoside structures.
Phytochemistry. 1996 May;42(1):213-6.
57: Guo T, Shi G, Seng H, Gao S, Chi W, Mu P, Ma Y, Jin B, Yang S.  
  [Preparation of huichun zhibao oral liquid (HZOL)]
Zhongguo Zhong Yao Za Zhi. 1996 Apr;21(4):219-22, 255.
58: Chen CC, Huang YL, Sun CM, Shen CC.  
  New prenylflavones from the leaves of Epimedium saggitatum.
J Nat Prod. 1996 Apr;59(4):412-4.
59: Sha M, Cao A, Yang S.  
  [Determination of chlorogenic acid in Epimedium koreanum Nakai by HPLC]
Zhongguo Zhong Yao Za Zhi. 1996 Feb;21(2):108-9, 128, inside back cover. Chinese.
60: Chen C, Sha M, Yang S.  
  [Quantitative changes of flavonoids in Epimedium koreanum Nakai in different collecting periods]
Zhongguo Zhong Yao Za Zhi. 1996 Feb;21(2):86-8, 127.
61: Nakai R, Shoyama Y, Shiraishi S.  
  Genetic characterization of Epimedium species using random amplified polymorphic DNA (RAPD) and PCR-restriction fragment length polymorphism (RFLP) diagnosis.
Biol Pharm Bull. 1996 Jan;19(1):67-70.
62: Lee MK, Choi YJ, Sung SH, Shin DI, Kim JW, Kim YC.  
  Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum.
Planta Med. 1995 Dec;61(6):523-6.
63: Sha M, Cao A, Yang S.  
  [Determination of hyperin in Epimedium koreanum Nakai by HPLC]
Zhongguo Zhong Yao Za Zhi. 1995 Jun;20(6):357-8, 384.
64: Liao HJ, Chen XM, Li WG.  
  [Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Apr;15(4):202-4.
65: Zheng J, Luo Y, Meng X, Sun Y, Zhang Y, Dong X, Shen W, Yang A, Xia C.  
  [Effects of Sichuan herba Epimedii on the concentration of plasma middle molecular substances and sulfhydryl group of "yang-deficiency" model animal]
Zhongguo Zhong Yao Za Zhi. 1995 Apr;20(4):238-9, 254.
66: Li Z, Liu S, Qian G, Li P.  
  [Determination of the content of icariine in four Chinese patent medicines containing Epimedium brevicornum Maxim]
Hua Xi Yi Ke Da Xue Xue Bao. 1995 Mar;26(1):66-9.
67: Chen X, Zhou M, Wang J.  
  [Effect of epimedium sagittatum on soluble IL-2 receptor and IL-6 levels in patients undergoing hemodialysis]
Zhonghua Nei Ke Za Zhi. 1995 Feb;34(2):102-4.
68: Li WK, Xiao PG, Tu GZ, Ma LB, Zhang RY.  
  Flavonol glycosides from Epimedium koreanum.
Phytochemistry. 1995 Jan;38(1):263-5.
69: Dong XP, Xiao CH, Zhang R, Li W.  
  [Chemical studies of Epimedium acuminatum Franch]
Zhongguo Zhong Yao Za Zhi. 1994 Oct;19(10):614-5, 639.
70: Li SY, Ping G, Geng L, Seow WK, Thong YH.  
  Immunopharmacology and toxicology of the plant flavonoid baohuoside-1 in mice.
Int J Immunopharmacol. 1994 Mar;16(3):227-31.
71: Cheng QL, Chen XM, Shi SZ.  
  [Effects of Epimedium sagittatum on immunopathology and extracellular matrices in rats with chronic renal insufficiency]
Zhonghua Nei Ke Za Zhi. 1994 Feb;33(2):83-6. Chinese.
72: Liu ZY, Yang YG, Zheng B.  
  [Effect of improving memory and inhibiting acetylcholinesterase activity by invigorating-qi and warming-yang recipe]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Nov;13(11):675-6, 646.
73: Liang HR, Yan WM, Li L, Jiang L, Dai L.  
  [Studies on the chemical constituents of Epimedium acuminatum Franch]
Zhongguo Zhong Yao Za Zhi. 1993 Nov;18(11):677-9, 703.
74: Shan Y.  
  [Effect of flavone glycosides of Epimedium koreanum on murine fibrinolytic system and apoplectic mortality]
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1992 Dec;14(6):419-23.
75: Hu BH, Zhou LD, Liu YL.  
  New tetrasaccharide flavonol glycoside from Epimedium acuminatum.
J Nat Prod. 1992 May;55(5):672-5.
76: Yamamoto H, Ieda K, Tsuchiya S, Yan K, Tanaka T, Iinuma M, Mizuno M.  
  Flavonol glycoside production in callus cultures of Epimedium diphyllum.
Phytochemistry. 1992 Mar;31(3):837-40.
77: Markham KR, Geiger H, Jaggy H.  
  Kaempferol-3-O-glucosyl(1-2)rhamnoside from Ginkgo biloba and a reappraisal of other gluco(1-2, 1-3 and 1-4)rhamnoside structures.
Phytochemistry. 1992 Mar;31(3):1009-11.
78: Hu BH, Zhou LD, Liu YL.  
  [Acuminatin from the aerial part of Epimedium acuminatum]
Yao Xue Xue Bao. 1992;27(5):397-400.
79: Liu F, Ding G, Li J.  
  [Effects of Epimedium sagittatum Maxim. Polysaccharides on DNA synthesis of bone marrow cells of "yang deficiency" animal model caused by hydroxyurea]
Zhongguo Zhong Yao Za Zhi. 1991 Oct;16(10):620-2, inside back cover.
80: Gu Y, Meng G.  
  [Preparation conditions for decoction of Epimedium grandiflorum Morr.]
Zhongguo Zhong Yao Za Zhi. 1990 Jul;15(7):412-3, 446.
81: Chen M, Kuang A, Chen J.  
  [Effect of monoamine neurotransmitters in the hypothalamus in a cortisol-induced rat model of yang-deficiency]
Zhong Xi Yi Jie He Za Zhi. 1990 May;10(5):292-4, 262.
82: Iinuma M, Tanaka T, Sakakibara N, Mizuno M, Matsuda H, Shiomoto H, Kubo M.  
  [Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system]
Yakugaku Zasshi. 1990 Mar;110(3):179-85.
83: Kuang AK, Chen JL, Chen MD.  
  [Effects of yang-restoring herb medicines on the levels of plasma corticosterone, testosterone and triiodothyronine]
Zhong Xi Yi Jie He Za Zhi. 1989 Dec;9(12):737-8, 710.
84: Yu YJ.  
  [Effect of tian-huang-ling granule in the treatment of allergic rhinitis]
Zhong Xi Yi Jie He Za Zhi. 1989 Dec;9(12):720-1, 708.
85: Zheng MS.  
  An experimental study of the anti-HSV-II action of 500 herbal drugs.
J Tradit Chin Med. 1989 Jun;9(2):113-6.
86: Mizuno M, Iinuma M, Tanaka T, Iwashima S, Sakakibara N.  
  [Seasonal fluctuation of flavonol glycosides in Epimedium species]
Yakugaku Zasshi. 1989 Apr;109(4):271-3.
87: Chen MD, Kuang AK, Chen JL.  
  [Influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule]
Zhong Xi Yi Jie He Za Zhi. 1989 Feb;9(2):93-5, 70.
88:    
  In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting.
Bull World Health Organ. 1989;67(6):613-8.
89: Xu LX, Zhang XQ.  
  Determination of total flavonoids in Epimedium brevicornum maxim by differential pulse polarography.
Yao Xue Xue Bao. 1989;24(8):606-10.
90: Gao ZF, Yang ZZ, Ma KC.  
  The stimulative effect of injection epimedium on the growth of chick embryo femur in vitro.
J Tradit Chin Med. 1988 Dec;8(4):305-6.
91: Liang HR, Yan WM, Li JS, Yang CS.  
  [Chemical studies of Epimedium wushanense T. S. Ying]
Yao Xue Xue Bao. 1988 Jan;23(1):34-7.
92: Li RS, Li JL, Xu JJ.  
  [Stimulatory action of Epimedium sagittatum (Sieb. et Zucc.) Maxim. on platelet aggregation in rats]
Zhong Yao Tong Bao. 1987 Aug;12(8):40-2, 64.
93: Liu FC.  
  [The treatment of leucopenia with inspissated granula of Epimedium sagittatum and its effects on serum Zn, Cu and Mg]
Zhong Xi Yi Jie He Za Zhi. 1985 Dec;5(12):719-21, 706. 
94: Gao ZF.  
  [Stimulant effect of Epimedium in an injection form on the growth of the chick embryo femur in vitro]
Zhong Xi Yi Jie He Za Zhi. 1985 Mar;5(3):172-4, 133.
95: Zhu SC.  
  [Clinical observations on 36 cases of viral myocarditis treated with Epimedium grandiflorum Moor and vitamin C]
Zhong Xi Yi Jie He Za Zhi. 1984 Sep;4(9):523-4, 514.
96: Liu FC.  
  [Effects of Epimedium sagittatum and Cistanche deserticola on DNA synthesis in "Yang-insufficiency" animal model induced by hydroxyurea]
Zhong Xi Yi Jie He Za Zhi. 1984 Aug;4(8):488-90.
97: Jin XL.  
  [Studies on the flavonoids of Epimedium sagittatum (author's transl)]
Zhong Yao Tong Bao. 1981 May;6(3):20-2. Chinese. No abstract available.
98: Tokuoka Y, Daigo K, Takemoto T.  
  [Studies on the constituents of Epimedium. V. Flavonoids of Epimedium grandiflorum Morr. (4) (author's transl)]
Yakugaku Zasshi. 1975 Jul;95(7):825-9.
99: Tokuoka Y, Daigo K, Takemoto T.  
  [Studies on the constituents of Epimedium. IV. Flavonoids of Epimedium gradiflorum Morr. (3) (author's transl)]
Yakugaku Zasshi. 1975 Jun;95(6):698-705.
100: Tokuoka Y, Daigo K, Takemoto T.  
  [Studies on the constituents of Epimedium. III. Lignoids of Epimedium grandiflorum Morr. (author's transl)]
Yakugaku Zasshi. 1975 May;95(5):557-63.
101: Tokuoka Y, Daigo K, Takemoto T.  
  [Studies on the constituents of Epimedium grandiflorum Morr. (2) (author's transl)]
Yakugaku Zasshi. 1975 Mar;95(3):321-5.
102: Takemoto T, Daigo K, Tokuoka Y.  
  [Studies on the constituents of Epimedium. I. Flavonoids of Epimedium grandiflorum Morr. (1) (author's transl)]
Yakugaku Zasshi. 1975 Mar;95(3):312-20.